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Details for messenger / hormone: sAPP

EndoNet ID: ENH00886

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Synonyms

  • sAPP total
  • sAPP
  • secreted form of APP
  • soluble amyloid precursor protein
  • secreted APP
  • soluble APP

General information

  • Secretion of amyloid precursor protein regulates differentiation of human neural stem cells. [1]
  • sAPP operates as a motogen in the human epidermis, where it may participate in the regulation of reepithelialization during wound healing. [2]
  • The amyloid precursor protein is proteolytically processed by beta- and gamma-secretases to release amyloid beta, the main component in senile plaques. Alternatively, APP can be cleaved within the amyloid beta domain by alpha-secretase releasing the non-amyloidogenic product sAPP alpha, which has been shown to have neuroprotective properties. [3]
  • sAPP enhances synaptogenesis, neurite outgrowth, cell survival and cell adhesion. [4]
  • Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. [5]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    • Anatomical structure: hippocampus

      Influenced by:

      • mGluR1
        in hippocampus
        • Glutamate-induced APP-S secretion required activation of phospholipase C, which resulted in inositol 1, 4,5-trisphosphate production, as shown by the rapid glutamate-induced accumulation of inositol 1,4,5-trisphosphate. [6]

    • Anatomical structure: cerebellar_cortex

      Influenced by:

      • mGluR1
        in cerebral_cortex
        • Glutamate-induced APP-S secretion required activation of phospholipase C, which resulted in inositol 1, 4,5-trisphosphate production, as shown by the rapid glutamate-induced accumulation of inositol 1,4,5-trisphosphate. [6]

    Targets

    Cell
    No records found.
    Reference