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Details for messenger / hormone: sAPPalpha

EndoNet ID: ENH00887

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  • amyloid intracellular domain 50
  • Gamma-CTF(50)
  • amyloid intracellular domain 57
  • Gamma-CTF(57)
  • amyloid intracellular domain 59
  • Gamma-CTF(59)
  • Beta-APP40
  • Beta-APP42
  • protease nexin-II
  • cerebral vascular amyloid peptide
  • PreA4
  • APPI
  • ABPP
  • Alzheimer disease amyloid protein
  • amyloid beta A4 protein
  • sAPPalpha
  • soluble amyloid precursor protein alpha
  • alpha-sAPP
  • secreted APP(alpha)
  • sAPP(alpha)
  • secreted N-terminal nonamyloidogenic APP
  • soluble APP-alpha

General information

  • Phospholipase A2 is involved in muscarinic receptor-mediated sAPPalpha release. [1]
  • Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage. [2]
  • The amyloid precursor protein is proteolytically processed by beta- and gamma-secretases to release amyloid beta, the main component in senile plaques. Alternatively, APP can be cleaved within the amyloid beta domain by alpha-secretase releasing the non-amyloidogenic product sAPP alpha, which has been shown to have neuroprotective properties. [3]
  • Interleukin-1alpha stimulates ADAM-17 synthesis, consistent with activation of the soluble fragment of Amyloid Precursor Protein (sAPPalpha) in human astrocytes. [4]


Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    UniProt P05067
    Ensembl ENST00000346798
    KEGG hsa:351
    • Anatomical structure: hippocampus

      Influenced by:

      • 5-hydroxytryptamine receptor 4
        in hippocampus
        • Activation of the human 5-HT(4) receptor stimulates the secretion of the non-amyloidogenic soluble form of the amyloid precursor protein (sAPPalpha). 5-HT enhanced the level of secreted sAPPalpha in a time- and dose-dependent manner in Chinese hamster ovary cells stably expressing the h5-HT(4) receptor isoform. [5]


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