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Details for messenger / hormone: tomoregulin-2 ectodomain

EndoNet ID: ENH00892

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  • TR2 ectodomain
  • transmembrane protein with EGF-like and two follistatin-like domains 2
  • tomoregulin
  • ectodomain of transmembrane protein TENB2
  • hyperplastic polyposis protein 1
  • transmembrane protein with EGF-like and two follistatin-like domains
  • Tomoregulin-2
  • tomoregulin-2 ectodomain
  • TR2 ECD
  • TMEFF2
  • HPP1

General information

  • The soluble extracellular domain of TMEFF2 increases survival of neuronal cells in primary cultures. [1]
  • Tomoregulin 2 is a glycosylated, single-pass type I, transmembrane protein with a unique extracellular domain, containing both an epidermal growth factor-like motif and two follistatin-like modules. The ECD can be cleaved by cell surface proteases, releasing it into the extracellular space. Cleavage is stimulated by pro-inflammatory cytokines interleukin-1β and tumor necrosis factor-α. The TR2 ECD functions as a neurotrophic factor for hippocampal and mesencephalic dopaminergic neurons, and appears to increase dendrite length in the latter cell type. [2]


Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Links to other resources

    UniProt Q9UIK5
    Ensembl ENST00000272771
    KEGG hsa:23671
    • Anatomical structure: brain

    • Anatomical structure: prostate


    No records found.