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Details for messenger / hormone: FABP4

EndoNet ID: ENH00896

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Synonyms

  • fatty acid-binding protein 4
  • adipocyte lipid-binding protein
  • A-FABP
  • aP2
  • adipocyte FABP
  • adipocyte P2
  • adipocyte-type fatty acid-binding protein
  • fatty acid-binding protein, adipocyte
  • FABP4

General information

  • Binds and activate HSL (hormone-sensitive lipase) [1]
  • A-FABP specifically enhances the activity of PPAR gamma [2]
  • Function: regulates fatty acid uptake and its intracellular transport. [3]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • lipocalins/fatty acid-binding proteins

      Composition

      Sequence 
      MCDAFVGTW KLVSSENFD DYMKEVGVG 
FATRKVAGM AKPNMIISV NGDVITIKS 
ESTFKNTEI SFILGQEFD EVTADDRKV 
KSTITLDGG VLVHVQKWD GKSTTIKRK 
REDDKLVVE CVMKGVTST RVYERA
      UniProt P15090

      Links to other resources

      UniProt P15090
      Ensembl ENST00000256104
      KEGG hsa:2167

      • Anatomical structure: monocyte

        Influenced by:

        • PPARgamma1
          in monocyte
          • FABP4, a known PPAR-gamma target, was strikingly increased by 24 h of treatment with two independent PPAR-gamma agonists. [4]

      • Anatomical structure: adipose_tissue

        • Is released from adipocytes and abundantly present in human serum. [1]

      Targets

      Cell
      No records found.
      Reference