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Details for messenger / hormone: insulin-like 3

EndoNet ID: ENH00902

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Synonyms

  • Leydig insulin-like peptide
  • Ley-I-L
  • relaxin-like factor
  • INSL3
  • RLNL
  • RLF
  • insulin-like 3

General information

  • NSL3 could also have important endocrine or paracrine roles in other tissues. Although defective spermatogenesis found in INSL3 or LGR8 null mice could be the secondary effects of cryptorchidism, Leydig cell-derived INSL3 could play a paracrine role in the testis because LGR8 is also expressed in the testis. In females, INSL3 is expressed in the luteal cells of the ovary through the estrous cycle and during pregnancy [1]

Classification

Hormone function

  • reproduction and sexual differentiation

Chemical classification

  • hormone
    • genome-encoded
      • insulin family

    Composition

    Insulin-like 3 B chain. (1 times)

    Sequence
    LGPAPTPEM REKLCGHHF VRALVRVCG 
    GPRWSTEA
    UniProt P51460

    Insulin-like 3 A chain. (1 times)

    Sequence
    AAATNPARY CCLSGCTQQ DLLTLCPY
    UniProt P51460

    Links to other resources

    UniProt P51460
    Ensembl ENST00000317306
    KEGG hsa:3640

      Targets

      Cellrelaxin receptor 2
      bone marrow Present
      brain Present
      kidney Present
      muscle Present
      peripheral blood leukocytes Present
      testis Present
      Phenotypes
      • Cryptorchidism
      thyroid gland Present
      uterus Present
      Reference