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Details for messenger / hormone: gastrin-17

EndoNet ID: ENH00910

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Synonyms

  • gastrin G17
  • gastrin-17
  • G17
  • component III
  • gastrin
  • gastrin component III
  • gastrin component II
  • Gastrin-34
  • gastrin component I

General information

  • A minor fraction of gastrin-17 is cleaved in G cells and released as short COOH-terminal peptides. These peptides have been identified in human antral tissue as a mixture of gastrin-7, -6, and -5, of which sulfated gastrin-6 is the predominant form released to antral venous blood. [1]
  • Stimulates acid secretion. [2]
  • Gastrin-17 is equipotent with gastrin-34 at similar plasma concentrations. [1]
  • See also gastrin (No 76).

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • gastrointestinal hormones
          • preprogastrin-derived peptides
            • classical gastrins

      Composition

      gastrin G17

      Sequence
      QGPWLEEEE EAYGWMDF

      Links to other resources

      UniProt P01350
      Ensembl ENST00000329402
      KEGG hsa:2520

        Targets

        CellCCK-2
        alpha cell of islet of Langerhans Present
        Influences
        • glucagon
        cell of adrenal gland zona glomerulosa Present
        Influences
        • aldosterone
        colon Present
        Phenotypes
        • induction of smooth muscle contraction
        D cell of gastrointestinal tract Present
        Influences
        • somatostatin
        • gastrin
        digestive system Present
        Influences
        • somatostatin
        enterochromaffin like cell Present
        Phenotypes
        • positive regulation of smooth muscle proliferation
        Influences
        • histamine
        hypothalamus Present
        Phenotypes
        • negative regulation of appetite
        intestinal smooth muscle cell Present
        Phenotypes
        • induction of smooth muscle contraction
        mucosa of small intestine Present
        neuron Present
        oxyntic cell of gastric gland Present
        Phenotypes
        • positive regulation of gastric acid secretion
        smooth muscle Present
        Reference