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Details for messenger / hormone: gastrin-6

EndoNet ID: ENH00914

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Synonyms

  • gastrin-6
  • G6
  • gastrin component III
  • Gastrin-17
  • gastrin component II
  • Gastrin-34
  • gastrin component I
  • Gastrin

General information

  • Sulfated and nonsulfated gastrin-6 are the smallest circulating bioactive gastrins in humans. [1]
  • Higher potency but a lower efficacy than gastrin-17. [1]
  • The efficacy of gastrin-6 is increased by tyrosine O-sulfation, which also enhances the protection against elimination. [1]
  • A minor fraction of gastrin-17 is cleaved in G cells and released as short COOH-terminal peptides. These peptides have been identified in human antral tissue as a mixture of gastrin-7, -6, and -5, of which sulfated gastrin-6 is the predominant form released to antral venous blood. [1]
  • See also gastrin (No 76).

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • gastrointestinal hormones
          • preprogastrin-derived peptides
            • non-classical gastrins

      Composition

      Gastrin-6.

      Sequence 
      YGWMDF

      Links to other resources

      UniProt P01350
      Ensembl ENST00000329402
      KEGG hsa:2520

      • Anatomical structure: G_cell

      Targets

      Cell
      No records found.
      Reference