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Details for messenger / hormone: REG1A

EndoNet ID: ENH00922

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Synonyms

  • REG1A
  • regenerating protein I alpha
  • lithostathine 1 alpha
  • pancreatic stone protein
  • PSP
  • pancreatic thread protein
  • PTP
  • islet of Langerhans regenerating protein
  • REG
  • islet cells regeneration factor
  • ICRF
  • regenerating islet-derived 1 alpha
  • Reg1alpha
  • regenerating islet-derived protein 1-alpha
  • Lithostathine-1-alpha

General information

  • Type I subclass member of the Reg gene family.
  • Expression of the Reg family of growth factors, which includes the pancreatitis associated proteins, is increased in reponse to damage and inflammation in a wide range of tissues including gastrointestinal tract, pancreas and nervous system. [1]
  • Reg increases proliferation of gastric epithelial cells, and mutations of Reg1alpha are also associated with ECL cell carcinoid tumours. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    Composition

    regenerating islet-derived 1 alpha

    Sequence 
    QEAQTELPQ ARISCPEGT NAYRSYCYY 
FNEDRETWV DADLYCQNM NSGNLVSVL 
TQAEGAFVA SLIKESGTD DFNVWIGLH 
DPKKNRRWH WSSGSLVSY KSWGIGAPS 
SVNPGYCVS LTSSTGFQK WKDVPCEDK 
FSFVCKFKN

    Links to other resources

    UniProt P05451
    Ensembl ENST00000233735
    KEGG hsa:5967

    • Anatomical structure: zymogenic_cell_of_gastric_gland

    • Anatomical structure: pancreas

    • Anatomical structure: digestive_system

    • Anatomical structure: central_nerve_system_element

    • Anatomical structure: enterochromaffin_like_cell

    • Anatomical structure: stomach

    Targets

    CellPutative tumor suppressor protein EXTL3
    beta cell of islet of Langerhans Present
    Phenotypes
    • regeneration of beta-cells of pancreas
    brain Present
    neuron Present
    Phenotypes
    • neurite elongation
    Reference