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Details for messenger / hormone: mucin-1 isoform 1

EndoNet ID: ENH00925

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Synonyms

  • MUC1-CT
  • breast carcinoma-associated antigen DF3
  • H23AG
  • tumor-associated epithelial membrane antigen
  • carcinoma-associated mucin
  • tumor-associated mucin
  • Episialin
  • PEMT
  • polymorphic epithelial mucin
  • Mucin-1
  • mucin-1 isoform 1
  • cleaved form of MUC1
  • mucin-1 isoform A
  • peanut-reactive urinary mucin

General information

  • MUC1 is proteolytically released from the surface of human uterine epithelial cells, and TACE/ADAM17 is a constitutive and PMA-stimulated MUC1 sheddase. [1]
  • In addition to TACE, MT1-MMP can mediate MUC1 ectodomain release. [1]
  • The cleaved form (only the isoform 1) of MUC1 forms a tight heterodimer with the released C-terminal peptide (which is first secreted to be extracellular). [2]

Classification

Hormone function

  • development and growth
    • cancer / metastasis

    Chemical classification

    Composition

    cleaved chain (potential)

    Sequence
    VVVQLTLAF REGTINVHD VETQFNQYK 
    TEAASRYNL TISDVSVSD VPFPFSAQS 
    GAGVPG
    UniProt P15941

    Links to other resources

    UniProt P15941-1
    Ensembl ENST00000433080
    KEGG hsa:4582

      Targets

      CellADAM17
      astrocyte Present
      brain Present
      cerebellar cortex Present
      cerebral cortex Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • regulation of angiogenesis
      hippocampus Present
      keratinocyte Present
      lung Present
      macrophage Present
      monocyte Present
      Phenotypes
      • ectodomain shedding
      neuron Present
      neutrophil granulocyte Present
      Phenotypes
      • ectodomain shedding
      T-lymphocyte Present
      Phenotypes
      • ectodomain shedding
      uterus Present
      Reference