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Details for messenger / hormone: sALCAM

EndoNet ID: ENH00928

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  • sALCAM
  • soluble isoform of activated leukocyte cell adhesion molecule
  • soluble ALCAM
  • soluble form of ALCAM
  • MEMD soluble isoform
  • CD166 soluble form
  • activated leukocyte cell adhesion molecule
  • CD166 antigen
  • cellular differentiation 166

General information

  • Produced via alternative splicing. [1]
  • sALCAM contains the single amino-terminal Ig-like domain of ALCAM and lacks a transmembrane domain. [1]
  • Binding of ALCAM to CD6 suggests that ALCAM may be involved in immune and/or inflammatory responses. [1]
  • sALCAM may modulate endothelial function through both ALCAM-dependent and ALCAM-independent pathways. [1]
  • sALCAM demonstrated an ability to bind ALCAM and partially inhibited ALCAM-ALCAM homophilic interactions. [1]
  • sALCAM expression is up-regulated after TNF-alpha treatment. [1]


Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    UniProt Q13740
    Ensembl ENST00000306107
    KEGG hsa:214
    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • Anatomical structure: vascularendothelial_cell

    • Anatomical structure: microvascularendothelial_cell