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Details for messenger / hormone: natural soluble CD5 form

EndoNet ID: ENH00929

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Synonyms

  • natural soluble CD5 form
  • sCD5
  • nsCD5
  • ssCD5
  • serum-soluble CD5
  • IgM-associated peptide
  • CT-2
  • SP-alpha
  • CD5 antigen-like

General information

  • Circulating soluble CD5 is suspected to participate in the pathogenesis of atopic dermatitis. [1]
  • N-glycosylated 52 kDa molecule. [2]
  • Present in human serum and resulting from proteolytic cleavage following lymphocyte activation. [3]
  • nsCD5 is released by proteolytic cleavage of the membrane form. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    UniProt P06127
    Ensembl ENST00000368174
    KEGG hsa:922
    • Anatomical structure: T-lymphocyte

    Targets

    CellCD5CD72
    B-lymphocyte Present
    Present
    Phenotypes
    • B cell response/activation
    • monocyte activation
    dendritic cell in lymphoid tissues Present
    Present
    Influences
    • IFN-gamma
    • SEMA4D
    lymphoid tissue Present
    macrophage Present
    Phenotypes
    • macrophage activation during immune response
    Influences
    • IFN-gamma
    • SEMA4D
    pancreas Present
    prolymphocyte Present
    spleen Present
    T-lymphocyte Present
    thymocyte Present
    tonsil Present
    Reference