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Details for messenger / hormone: soluble E-selectin

EndoNet ID: ENH00934

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Synonyms

  • sE-sel
  • soluble E-selectin
  • sE-selectin
  • secreted endothelial leukocyte adhesion molecule 1
  • ELAM-1
  • leukocyte-endothelial cell adhesion molecule 2 soluble form
  • LECAM2
  • CD62E
  • sSELE
  • CD62 antigen-like family member E
  • leukocyte-endothelial cell adhesion molecule 2
  • endothelial leukocyte adhesion molecule 1
  • E-selectin
  • sES

General information

  • Serum levels of sES are associated with the clinical course of liver metastases from breast cancer. [1]
  • Soluble E-selectin is an angiogenic mediator. [2]
  • Release of E-selectin from endothelial cell surface occurs upon induction of apoptosis requiring caspase activation. [3]
  • TNFalpha significantly increases E-selectin surface expression. [3]
  • E-selectin synthesis is upregulated in activated endothelial cells. [4]

Classification

Hormone function

  • development and growth
    • cancer / metastasis
      • apoptosis

      Chemical classification

      Links to other resources

      UniProt P16581
      Ensembl ENST00000333360
      KEGG hsa:6401

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: umbilical_vein_endothelial_cells

      Targets

      CellESL-1
      lymphocyte Present
      Influences
      • ↓ FGF-3
      Reference