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Details for messenger / hormone: soluble ectodomain of transferrin receptor

EndoNet ID: ENH00935

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  • transferrin receptor protein 1 soluble form
  • shedded CD71
  • processed sTfR form
  • TFRC
  • TfR1
  • p90
  • T9
  • transferrin receptor protein 1
  • soluble ectodomain of transferrin receptor

General information

  • Shedding of the ectodomain of the transferrin receptor is promoted by ADAM17. [1]
  • function: promotes loss of cell cell adhesion, thus promoting tumor development [2]


Hormone function

  • development and growth
    • cancer / metastasis

    Chemical classification

    Links to other resources

    UniProt P02786
    Ensembl ENST00000426789
    KEGG hsa:7037


      astrocyte Present
      brain Present
      cerebellar cortex Present
      cerebral cortex Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      • regulation of angiogenesis
      hippocampus Present
      keratinocyte Present
      lung Present
      macrophage Present
      monocyte Present
      • ectodomain shedding
      neuron Present
      neutrophil granulocyte Present
      • ectodomain shedding
      T-lymphocyte Present
      • ectodomain shedding
      uterus Present