Status
Please wait ...

Details for messenger / hormone: soluble ectodomain of transferrin receptor

EndoNet ID: ENH00935

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • transferrin receptor protein 1 soluble form
  • shedded CD71
  • processed sTfR form
  • TFRC
  • TfR1
  • p90
  • T9
  • transferrin receptor protein 1
  • soluble ectodomain of transferrin receptor

General information

  • Shedding of the ectodomain of the transferrin receptor is promoted by ADAM17. [1]
  • function: promotes loss of cell cell adhesion, thus promoting tumor development [2]

Classification

Hormone function

  • development and growth
    • cancer / metastasis

    Chemical classification

    Links to other resources

    UniProt P02786
    Ensembl ENST00000426789
    KEGG hsa:7037

      Targets

      CellADAM17
      astrocyte Present
      brain Present
      cerebellar cortex Present
      cerebral cortex Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Phenotypes
      • regulation of angiogenesis
      hippocampus Present
      keratinocyte Present
      lung Present
      macrophage Present
      monocyte Present
      Phenotypes
      • ectodomain shedding
      neuron Present
      neutrophil granulocyte Present
      Phenotypes
      • ectodomain shedding
      T-lymphocyte Present
      Phenotypes
      • ectodomain shedding
      uterus Present
      Reference