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Details for messenger / hormone: elastase-2

EndoNet ID: ENH00938

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Synonyms

  • elastase-2
  • neutrophil elastase
  • ELA2
  • elastase 2
  • NE
  • PMN-E
  • HNE
  • HLE
  • bone marrow serine protease
  • leukocyte elastase
  • medullasin
  • polymorphonuclear elastase
  • human leukocyte elastase
  • PMN elastase

General information

  • CRP degradation products generated by neutrophil elastase promote neutrophil apoptosis. [1]
  • Neutrophil elastase is capable of digesting virtually every type of matrix protein, including several types of collagen, fibronectin, proteoglycans, heparin, and cross-linked fibrin. [2]
  • Alpha-melanocyte-stimulating hormone down-regulates CXC receptors through activation of neutrophil elastase. [1]
  • NE increases IL-8 transcription through p38/NF-kappaB activation via EGFR transactivation. [3]
  • Soluble neutrophil-derived protease.
  • The biological roles of neutrophil elastase also include acting as a secretagogue for cytokines, glycosaminoglycans, and mucin, in addition to acting as a modulator of inflammation. [2]
  • Mutations in ELA2, the gene encoding neutrophil elastase, cause the human diseases cyclic neutropenia and severe congenital neutropenia. [4]
  • Involved in the tissue destruction and inflammation that characterize numerous diseases, including hereditary emphysema, chronic obstructive pulmonary disease, cystic fibrosis, adult respiratory distress syndrome, ischemic-reperfusion injury and rheumatoid arthritis. [5]
  • Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF. [6]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    UniProt P08246
    Ensembl ENST00000263621
    KEGG hsa:1991

    • Anatomical structure: blood

    • Anatomical structure: monocyte

    • Anatomical structure: neutrophil_granulocyte

    • Anatomical structure: blood_vessel

    • Anatomical structure: vascularendothelial_cell

    • Anatomical structure: bone_marrow

    • Anatomical structure: heart

    • Anatomical structure: leukocyte

    • Anatomical structure: macrophage

    • Anatomical structure: microvascularendothelial_cell

    • Anatomical structure: myelocyte

    • Anatomical structure: lung

    Targets

    CellPAR1
    lymph node Present
    Phenotypes
    • positive regulation of myeloid dendritic cell activation
    Reference