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Details for messenger / hormone: SLAMF1 isoform 3

EndoNet ID: ENH00952

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Synonyms

  • SLAMF1 isoform 3
  • signaling lymphocytic activation molecule isoform 3
  • IPO-3 secreted form
  • CDw150 secreted isoform
  • soluble form of CD150 antigen
  • sSLAM
  • secreted SLAM
  • soluble SLAM
  • CDw150
  • IPO-3
  • signaling lymphocytic activation molecule

General information

  • Strongly up-regulated in DC activated through CD40, as well as in response to inflammatory stimuli, including polyinosinic polycytidylic acid and LPS. [1]
  • SLAM up-regulation appears to be a direct result of the induction of DC maturation, as inflammatory cytokines released during this process do not affect SLAM expression. [1]
  • Engagement of SLAM enhances DC production of IL-12 and IL-8, while having no effect on production of IL-10. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    UniProt Q13291
    Ensembl ENST00000302035
    KEGG hsa:6504
    • Anatomical structure: T-lymphocyte

    • Anatomical structure: dendritic_cell_in_lymphoid_tissues

    Targets

    Reference