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Details for messenger / hormone: elafin

EndoNet ID: ENH00963

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Synonyms

  • elafin
  • trappin
  • elastase-specific inhibitor
  • ESI
  • skin-derived antileukoproteinase
  • SKALP
  • peptidase inhibitor 3
  • WAP four-disulfide core domain protein 14
  • protease inhibitor WAP3
  • PI3
  • WFDC14

General information

  • Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. [1]
  • Adenoviral E1A suppresses secretory leukoprotease inhibitor and elafin secretion in human alveolar epithelial cells and bronchial epithelial cells. [2]
  • Elafin and its precursor trappin-2 (also called pre-elafin) are potent protein inhibitors of neutrophil serine proteases such as leukocyte elastase and proteinase 3. [3]

Classification

Hormone function

  • homeostasis
    • pulmonary control

    Chemical classification

    Links to other resources

    UniProt P19957
    Ensembl ENST00000243924
    KEGG hsa:5266

    • Anatomical structure: monocyte

    • Anatomical structure: macrophage

    • Anatomical structure: alveolar_macrophage

    • Anatomical structure: neutrophil_granulocyte

    Targets

    Cell
    No records found.
    Reference