Status
Please wait ...

Details for messenger / hormone: free PSA

EndoNet ID: ENH00965

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • free PSA
  • free prostate specific antigen
  • fPSA
  • KLK3
  • APS
  • HK3
  • KLK2A1
  • free noncomplex PSA
  • nicked PSA
  • kallikrein-3
  • kallikrein 3
  • semenogelase
  • gamma-seminoprotein
  • seminin
  • P-30 antigen
  • prostate-specific antigen

General information

  • The unbound form of PSA has been shown to be up-regulated by several hormones, including estrogens or progestins. [1]
  • Enzymatically inactive form of PSA.
  • Prostate specific antigen gene expression is regulated by androgen receptor. [2]
  • The ratio of free-to-total PSA is decreased in patients with prostate cancer.

Classification

Hormone function

  • reproduction and sexual differentiation
    • sexual differentiation

    Chemical classification

    Links to other resources

    UniProt P07288
    Ensembl ENST00000326003
    KEGG hsa:354
    • Anatomical structure: prostate

      Influenced by:

      • SHBG-R
        in prostate
        • The gene for prostate-specific antigen (PSA) contains an androgen response element. After binding its cognate ligand, the androgen receptor (AR) interacts with this response element to initiate PSA mRNA transcription and secretion. In the absence of androgens, E2 in concert with SHBG-RSHBG, acts at the cell membrane to cause secretion of PSA and that this effect is blocked by anti-androgens. [3]

    Targets

    CellLRP1
    No records found.
    Reference