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Details for messenger / hormone: slit-1

EndoNet ID: ENH00976

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Synonyms

  • slit-1
  • slit homolog 1 protein
  • multiple epidermal growth factor-like domains 4
  • SLIT1
  • MEGF4
  • SLIL1
  • multiple epidermal growth factor-like domains protein 4

General information

  • Interaction with GREM1 leads to inhibition.
  • SLIT-ROBO signaling pathway is implicated in neurogenesis, angiogenesis, and immune response through the regulation of axonal guidance, endothelial cell migration, and denderitic cell migration, respectively. [1]
  • SLIT1 expression is neuronal specific. [2]
  • Contains leucine-rich repeats and EGF-like motifs.
  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [1]
  • Heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction. [3]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • development and growth
      • growth stimulation
        • embryogenesis
        • immune response
          • activation

          Chemical classification

          Composition

          Slit homolog 1 protein, isoform 1.

          • SLIT1 gene at human chromosome 10q24.1. [1]
          Sequence 
          CPALCTCTG TTVDCHGTG LQAIPKNIP 
RNTERLELN GNNITRIHK NDFAGLKQL 
RVLQLMENQ IGAVERGAF DDMKELERL 
RLNRNQLHM LPELLFQNN QALSRLDLS 
ENAIQAIPR KAFRGATDL KNLQLDKNQ 
ISCIEEGAF RALRGLEVL TLNNNNITT 
IPVSSFNHM PKLRTFRLH SNHLFCDCH 
LAWLSQWLR QRPTIGLFT QCSGPASLR 
GLNVAEVQK SEFSCSGQG EAGRVPTCT 
LSSGSCPAM CTCSNGIVD CRGKGLTAI 
PANLPETMT EIRLELNGI KSIPPGAFS 
PYRKLRRID LSNNQIAEI APDAFQGLR 
SLNSLVLYG NKITDLPRG VFGGLYTLQ 
LLLLNANKI NCIRPDAFQ DLQNLSLLS 
LYDNKIQSL AKGTFTSLR AIQTLHLAQ 
NPFICDCNL KWLADFLRT NPIETSGAR 
CASPRRLAN KRIGQIKSK KFRCSAKEQ 
YFIPGTEDY QLNSECNSD VVCPHKCRC 
EANVVECSS LKLTKIPER IPQSTAELR 
LNNNEISIL EATGMFKKL THLKKINLS 
NNKVSEIED GAFEGAASV SELHLTANQ 
LESIRSGMF RGLDGLRTL MLRNNRISC 
IHNDSFTGL RNVRLLSLY DNQITTVSP 
GAFDTLQSL STLNLLANP FNCNCQLAW 
LGGWLRKRK IVTGNPRCQ NPDFLRQIP 
LQDVAFPDF RCEEGQEEG GCLPRPQCP 
QECACLDTV VRCSNKHLR ALPKGIPKN 
VTELYLDGN QFTLVPGQL STFKYLQLV 
DLSNNKISS LSNSSFTNM SQLTTLILS 
YNALQCIPP LAFQGLRSL RLLSLHGND 
ISTLQEGIF ADVTSLSHL AIGANPLYC 
DCHLRWLSS WVKTGYKEP GIARCAGPQ 
DMEGKLLLT TPAKKFECQ GPPTLAVQA 
KCDLCLSSP CQNQGTCHN DPLEVYRCA 
CPSGYKGRD CEVSLNSCS SGPCENGGT 
CHAQEGEDA PFTCSCPTG FEGPTCGVN 
TDDCVDHAC ANGGVCVDG VGNYTCQCP 
LQYEGKACE QLVDLCSPD LNPCQHEAQ 
CVGTPDGPR CECMPGYAG DNCSENQDD 
CRDHRCQNG AQCMDEVNS YSCLCAEGY 
SGQLCEIPP HLPAPKSPC EGTECQNGA 
NCVDQGNRP VCQCLPGFG GPECEKLLS 
VNFVDRDTY LQFTDLQNW PRANITLQV 
STAEDNGIL LYNGDNDHI AVELYQGHV 
RVSYDPGSY PSSAIYSAE TINDGQFHT 
VELVAFDQM VNLSIDGGS PMTMDNFGK 
HYTLNSEAP LYVGGMPVD VNSAAFRLW 
QILNGTGFH GCIRNLYIN NELQDFTKT 
QMKPGVVPG CEPCRKLYC LHGICQPNA 
TPGPMCHCE AGWVGLHCD QPADGPCHG 
HKCVHGQCV PLDALSYSC QCQDGYSGA 
LCNQAGALA EPCRGLQCL HGHCQASGT 
KGAHCVCDP GFSGELCEQ ESECRGDPV 
RDFHQVQRG YAICQTTRP LSWVECRGS 
CPGQGCCQG LRLKRRKFT FECSDGTSF 
AEEVEKPTK CGCALCA
          UniProt O75093

          Links to other resources

          UniProt O75093
          Ensembl ENST00000266058
          KEGG hsa:6585

          • Anatomical structure: brain

            • SLIT1 expression is neuronal specific. [2]

          • Anatomical structure: neuron

            • SLIT1 expression is neuronal specific. [2]

          • Anatomical structure: central_nerve_system_element

          Targets

          CellROBO1syndecan
          brain Present
          neutrophil granulocyte Present
          placenta Present
          spinal cord Present
          thymus Present
          uterus Present
          Reference