Status
Please wait ...

Details for messenger / hormone: slit-2 isoform 1 C-product

EndoNet ID: ENH00977

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • slit-2 isoform 1 C-product
  • slit homolog 2 protein isoform 1 C-product
  • SLIT2 isoform 1 C-product
  • SLIL3 isoform 1 C-product
  • neurogenic extracellular slit
  • slit2-C
  • slit homolog 2 protein

General information

  • Promoter region hypermethylation and transcriptional silencing of SLIT2 in lung, breast, colorectal and glioma cell lines and primary tumours have been reported. [1]
  • Slit2 is cleaved into Slit2-N, a protein tightly binding to cell membranes, and Slit2-C, a diffusible fragment. [2]
  • Slit2, a neuronal repellent factor, is up-regulated in the skin by allergen sensitization and down-regulates the migration of Langerhans cells. [3]
  • Interacts with glypican 1.
  • Netrin-1 and Slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. [4]
  • Slit2 is a repellent for retinal ganglion cell axons. [5]
  • Slit2 can act bifunctionally, both repulsing and stimulating the motility of trunk neural crest cells. [6]
  • Heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction. [7]
  • Re-expression of SLIT2 inhibits the growth of cancer cell lines so that SLIT2 appears to function as a novel tumour suppressor gene. [1]
  • The neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. [2]
  • EphrinA5 and slit2 are important repulsive guidance cues in the developing retinotectal system. [8]
  • On binding to Robo receptors, Slit2 repels developing axons and inhibits leukocyte chemotaxis. [2]
  • SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. [9]

Classification

Hormone function

  • development and growth
    • cancer / metastasis
      • growth stimulation

      Chemical classification

      Composition

      Slit homolog 2 protein isoform 1 C-product.

      • SLIT2 gene at 4p15.31. [10]
      Sequence 
      TSPCDNFDC QNGAQCIVR INEPICQCL 
PGYQGEKCE KLVSVNFIN KESYLQIPS 
AKVRPQTNI TLQIATDED SGILLYKGD 
KDHIAVELY RGRVRASYD TGSHPASAI 
YSVETINDG NFHIVELLA LDQSLSLSV 
DGGNPKIIT NLSKQSTLN FDSPLYVGG 
MPGKSNVAS LRQAPGQNG TSFHGCIRN 
LYINSELQD FQKVPMQTG ILPGCEPCH 
KKVCAHGTC QPSSQAGFT CECQEGWMG 
PLCDQRTND PCLGNKCVH GTCLPINAF 
SYSCKCLEG HGGVLCDEE EDLFNPCQA 
IKCKHGKCR LSGLGQPYC ECSSGYTGD 
SCDREISCR GERIRDYYQ KQQGYAACQ 
TTKKVSRLE CRGGCAGGQ CCGPLRSKR 
RKYSFECTD GSSFVDEVE KVVKCGCTR 
CVS
      UniProt O94813

      Links to other resources

      UniProt O94813
      Ensembl ENST00000273739
      KEGG hsa:9353

      • Anatomical structure: spinal_cord

      • Anatomical structure: adrenal_gland

      • Anatomical structure: artery

      • Anatomical structure: glomerulus

      • Anatomical structure: distal_tubule_of_nephron

      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: glial_cell_of_central_nervous_system

      • Anatomical structure: retina

      Targets

      Cellglypican 1ROBO1ROBO2syndecan
      bone marrow Present
      brain Present
      		Present
      		Present
      breast Present
      mammary gland Present
      neutrophil granulocyte Present
      ovary Present
      		Present
      placenta Present
      propria mucosa of bronchus Present
      skeleton muscle Present
      spinal cord Present
      		Present
      thymus Present
      uterus Present
      Reference