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Details for messenger / hormone: slit-3 isoform 1

EndoNet ID: ENH00979

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Synonyms

  • slit-3 isoform 1
  • slit homolog 3 protein isoform 1
  • multiple epidermal growth factor-like domains 5 isoform 1
  • SLIT3 isoform 1
  • MEGF5 isoform 1
  • SLIL2 isoform 1
  • multiple epidermal growth factor-like domains protein 5
  • slit homolog 3 protein

General information

  • Slit3 protein is targeted to and localized at two distinct sites within epithelial cells: the mitochondria, and then, in more confluent cells, the cell surface. Targeting to both locations is driven by specific NH(2)-terminal sequences. [1]
  • Heparin/HS is an integral component of the minimal Slit-Robo signaling complex and serves to stabilize the relatively weak Slit-Robo interaction. [2]
  • Function: unknown, but due to distinct localization, its function might be different then for the other slit proteins. [1]

Classification

Hormone function

Chemical classification

Composition

Slit homolog 3 protein.

  • SLIT3 gene at 5q34-q35.1. [3]
  • Contains 23 LRR (leucine-rich) repeats, 9 EGF-like domains, 1 CTCK (C-terminal cystine knot-like) domain and 1 laminin G-like domain. [4]
Sequence
CPTKCTCSA ASVDCHGLG LRAVPRGIP 
RNAERLDLD RNNITRITK MDFAGLKNL 
RVLHLEDNQ VSVIERGAF QDLKQLERL 
RLNKNKLQV LPELLFQST PKLTRLDLS 
ENQIQGIPR KAFRGITDV KNLQLDNNH 
ISCIEDGAF RALRDLEIL TLNNNNISR 
ILVTSFNHM PKIRTLRLH SNHLYCDCH 
LAWLSDWLR QRRTVGQFT LCMAPVHLR 
GFNVADVQK KEYVCPAPH SEPPSCNAN 
SISCPSPCT CSNNIVDCR GKGLMEIPA 
NLPEGIVEI RLEQNSIKA IPAGAFTQY 
KKLKRIDIS KNQISDIAP DAFQGLKSL 
TSLVLYGNK ITEIAKGLF DGLVSLQLL 
LLNANKINC LRVNTFQDL QNLNLLSLY 
DNKLQTISK GLFAPLQSI QTLHLAQNP 
FVCDCHLKW LADYLQDNP IETSGARCS 
SPRRLANKR ISQIKSKKF RCSGSEDYR 
SRFSSECFM DLVCPEKCR CEGTIVDCS 
NQKLVRIPS HLPEYVTDL RLNDNEVSV 
LEATGIFKK LPNLRKINL SNNKIKEVR 
EGAFDGAAS VQELMLTGN QLETVHGRV 
FRGLSGLKT LMLRSNLIG CVSNDTFAG 
LSSVRLLSL YDNRITTIT PGAFTTLVS 
LSTINLLSN PFNCNCHLA WLGKWLRKR 
RIVSGNPRC QKPFFLKEI PIQDVAIQD 
FTCDGNEES SCQLSPRCP EQCTCMETV 
VRCSNKGLR ALPRGMPKD VTELYLEGN 
HLTAVPREL SALRHLTLI DLSNNSISM 
LTNYTFSNM SHLSTLILS YNRLRCIPV 
HAFNGLRSL RVLTLHGND ISSVPEGSF 
NDLTSLSHL ALGTNPLHC DCSLRWLSE 
WVKAGYKEP GIARCSSPE PMADRLLLT 
TPTHRFQCK GPVDINIVA KCNACLSSP 
CKNNGTCTQ DPVELYRCA CPYSYKGKD 
CTVPINTCI QNPCQHGGT CHLSDSHKD 
GFSCSCPLG FEGQRCEIN PDDCEDNDC 
ENNATCVDG INNYVCICP PNYTGELCD 
EVIDHCVPE LNLCQHEAK CIPLDKGFS 
CECVPGYSG KLCETDNDD CVAHKCRHG 
AQCVDTING YTCTCPQGF SGPFCEHPP 
PMVLLQTSP CDQYECQNG AQCIVVQQE 
PTCRCPPGF AGPRCEKLI TVNFVGKDS 
YVELASAKV RPQANISLQ VATDKDNGI 
LLYKGDNDP LALELYQGH VRLVYDSLS 
SPPTTVYSV ETVNDGQFH SVELVTLNQ 
TLNLVVDKG TPKSLGKLQ KQPAVGINS 
PLYLGGIPT STGLSALRQ GTDRPLGGF 
HGCIHEVRI NNELQDFKA LPPQSLGVS 
PGCKSCTVC KHGLCRSVE KDSVVCECR 
PGWTGPLCD QEARDPCLG HRCHHGKCV 
ATGTSYMCK CAEGYGGDL CDNKNDSAN 
ACSAFKCHH GQCHISDQG EPYCLCQPG 
FSGEHCQQE NPCLGQVVR EVIRRQKGY 
ASCATASKV PIMECRGGC GPQCCQPTR 
SKRRKYVFQ CTDGSSFVE EVERHLECG 
CLACS
UniProt O75094

Links to other resources

UniProt O75094
Ensembl ENST00000332966
KEGG hsa:6586
  • Anatomical structure: testis

  • Anatomical structure: brain

  • Anatomical structure: thyroid_gland

Targets

CellROBO1syndecan
brain Present
neutrophil granulocyte Present
placenta Present
spinal cord Present
thymus Present
uterus Present
Reference