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Details for messenger / hormone: 6-trans-LTB4

EndoNet ID: ENH00992

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Synonyms

  • 6-trans-LTB4
  • 6-trans leukotriene B4
  • 5S,12R-dihydroxy-6E,8E,10E,14Z-eicosatetraenoic acid

General information

  • 6-trans-LTB4 is metabolized by a hydroxylase in human polymorphonuclear leukocytes to 20-hydroxy metabolites. [1]
  • 6-trans-LTB4 is transformed to a dihydro metabolite and further omega-hydroxylated. [2]
  • 6-trans-LTB4 is metabolized to either 5,12,20-trihydroxy-6,8,14-eicosatrienoic acid or 5,12,20-trihydroxy-8,10,14-eicosatrienoic acid in a second pathway. [1]

Classification

Hormone function

Chemical classification

  • hormone
    • not genome-encoded
      • eicosanoids/fatty acid derivatives
        • leukotrienes

    Composition

    Links to other resources

    LIPID MAPS LMFA03020013
    LipidBank XPR3115

      Targets

      CellCysLTR1LTB4-R1LTB4-R2
      brain Present
      colon Present
      heart Present
      		Present
      leukocyte Present
      		Present
      lung Present
      lymphoid tissue Present
      pancreas Present
      peripheral blood leukocytes Present
      placenta Present
      skeleton muscle Present
      small intestine Present
      spleen Present
      Reference