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Details for messenger / hormone: 20-hydroxy LTB4

EndoNet ID: ENH01000

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Synonyms

  • 20-hydroxy leukotriene B4
  • 20-hydroxy LTB4
  • 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
  • 20-OH-LTB4
  • omega-Hydroxy-LTB4

General information

  • administration of extremely low doses of 20- hydroxy LTB4 can effectively block inflammatory responses to LTB4 [1]
  • 20-hydroxy LTB4 selectively inhibited neutrophil chemotaxis to LTB4 and reduced the number of high affinity receptors for LTB4 [1]
  • omega-hydroxylated metabolite of leukotriene B4 in human neutrophils (by a specific cytochrome P450s (CYP4F) ) [1]
  • Elevated urinary concentrations are found in patients with Sjogren-Larsson syndrome [2]
  • binds to LTB4 receptors on neutrophils with 10-20 times less affinity than LTB4 [1]
  • 20-hydroxy LTB4 inhibits neutrophil responses to LTB4 [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • leukotrienes

      Composition

      Links to other resources

      KEGG C04853
      LIPID MAPS LMFA03020018
      LipidBank XPR3120

      • Anatomical structure: neutrophil_granulocyte

      Targets

      CellCysLTR1LTB4-R1LTB4-R2
      brain Present
      colon Present
      heart Present
      		Present
      leukocyte Present
      		Present
      lung Present
      lymphoid tissue Present
      pancreas Present
      peripheral blood leukocytes Present
      placenta Present
      skeleton muscle Present
      small intestine Present
      spleen Present
      Reference