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Details for messenger / hormone: 20-hydroxy LTB4

EndoNet ID: ENH01000

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  • 20-hydroxy leukotriene B4
  • 20-hydroxy LTB4
  • 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
  • (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid
  • 20-OH-LTB4
  • omega-Hydroxy-LTB4

General information

  • administration of extremely low doses of 20- hydroxy LTB4 can effectively block inflammatory responses to LTB4 [1]
  • 20-hydroxy LTB4 selectively inhibited neutrophil chemotaxis to LTB4 and reduced the number of high affinity receptors for LTB4 [1]
  • omega-hydroxylated metabolite of leukotriene B4 in human neutrophils (by a specific cytochrome P450s (CYP4F) ) [1]
  • Elevated urinary concentrations are found in patients with Sjogren-Larsson syndrome [2]
  • binds to LTB4 receptors on neutrophils with 10-20 times less affinity than LTB4 [1]
  • 20-hydroxy LTB4 inhibits neutrophil responses to LTB4 [1]


Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • leukotrienes


      Links to other resources

      KEGG C04853
      LIPID MAPS LMFA03020018
      LipidBank XPR3120
      • Anatomical structure: neutrophil_granulocyte


      brain Present
      colon Present
      heart Present
      leukocyte Present
      lung Present
      lymphoid tissue Present
      pancreas Present
      peripheral blood leukocytes Present
      placenta Present
      skeleton muscle Present
      small intestine Present
      spleen Present