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Details for messenger / hormone: LXA4

EndoNet ID: ENH01003

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Synonyms

  • LXA4
  • lipoxin A4
  • 5S,6R-LipoxinA4
  • 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid

General information

  • LXA4 is a lipid mediator that plays an important role in the resolution of inflammation. [1]
  • LXA4 displays a rapid and acute onset anti-edematogenic activity. [1]
  • LXA4 plays a novel role as a potent modulator of matrix accumulation and pro-fibrotic change that is protective in progressive renal disease. [2]

Classification

Hormone function

  • immune response

Chemical classification

  • hormone
    • not genome-encoded
      • eicosanoids/fatty acid derivatives
        • lipoxins

    Composition

    Links to other resources

    KEGG C06314
    LIPID MAPS LMFA03040001
    LipidBank XPR4001

      Targets

      CellCysLTR1FPRL1
      colon Present
      heart Present
      lung Present
      Present
      monocyte Present
      Phenotypes
      • monocyte activation
      neutrophil granulocyte Present
      pancreas Present
      peripheral blood leukocytes Present
      placenta Present
      small intestine Present
      spleen Present
      Reference