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Details for messenger / hormone: resolvin E1

EndoNet ID: ENH01043

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Synonyms

  • resolvin E1
  • 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid
  • RvE1

General information

  • Resolvin E1 is potent agonists for resolution of inflamed tissues. [1]
  • Resolvin E1 act directly on the migration of neutrophils to attenuate transendothelial migration. [2]
  • Resolvin E1 binds to LTB(4) receptor 1 (BLT1) as a partial agonist, which served as a local damper of BLT1 signals on leukocytes along with other receptors,to mediate the resolution of inflammation. [3]
  • The conversion of RvE1 to the oxo product causess the RvE1 inactivation, this mode is a useful tool to evaluate the actions of RvE1 in complex disease models. [4]
  • RvE1 is a therapeutic agent in an in vivo leukocyte- and osteoclast-mediated inflammatory disease, it acts as a modulator of the inflammatory response shifting the response to more rapid resolution and effectively preventing the chronic phase. [5]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • hydroxy/hydroperoxyeicosapentaenoic acids

      Composition

      Links to other resources

      LIPID MAPS LMFA03070019

        Targets

        CellCMKLR1
        chondrocyte Present
        Influences
        • interleukin 6
        • IL-8
        dendritic cell in lymphoid tissues Present
        Phenotypes
        • dendritic cell chemotaxis
        endothelial cell Present
        Phenotypes
        • angiogenesis
        macrophage Present
        Phenotypes
        • chemotaxis of macrophages
        Reference