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Details for messenger / hormone: 5-Oxo-ETE

EndoNet ID: ENH01045

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  • 5-Oxo-ETE
  • 5-OxoETE/5-KETE
  • 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid

General information

  • 5-Oxo-ETE is a strong activator of human eosinophils with a chemotactic potency comparable to those of eotaxin and RANTES, both of wwhich enhance 5-oxo-ETE-induced chemotaxis. [1]
  • Epithelial cells are a major source of 5-oxo-ETE under conditions of oxidative stress, which may contribute to eosinophil infiltration in allergic diseases. [2]
  • Exposure of the endothelium to oxidative stress and inflammation result in the synthesis of 5-oxo-ETE, which could then induce the infiltration of inflammatory cells into the tissue. [3]
  • 5-oxoER is critical for prostate cancer cell survival, and that the 5-LOX metabolite, 5-oxoETE, controls survival of prostate cancer cells through its own G-protein-coupled receptor, 5-oxoER. [4]
  • 5-oxo-ETE is the most effective in stimulating migration of human eosinophils. [5]
  • 5-oxo-ETE is a potent activator of human eosinophils and may be an important regulator of tissue infiltration of these cells. [6]
  • Phorbol myristate acetate-activated human polymorphonuclear leukocytes can synthesize substantial amounts of 5-oxo-ETE. [7]
  • 5-OxoETE regulates a biologic profile well suited for mediating Eo-dominated allergic reactions in vivo. [8]
  • 5-oxo-ETE can induce the release of any cytokine, which is an important mediator in allergic and other inflammatory diseases due both to its chemoattractant properties and to its potent effects on the synthesis of the survival factor granulocyte/macrophage colony-stimulating factor. [9]
  • The lung tissue from patients with severe pulmonary hypertension is under oxidant stress and peroxynitrite as well as several HETEs and 5-oxo-ETE are being formed in the lung tissue. [10]
  • 5-Oxo-ETE eicosanoid activates a specific K(+) conductance, which reduces Ca(2+) entry and facilitates relaxation of smooth muscle cells. [11]
  • 5-Oxo-ETE is oxidated reversible from 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid since human polymorphonuclear leukocytes microsomes stereospecifically reduce 5-oxo-ETE to the 5(S)-hydroxy compound in the presence of NADPH. [12]
  • 5-oxo-ETE is potentially involved in the regulation of basophil recruitment and hence is a useful therapeutic target in atopic disease. [13]
  • Among 5-LO products, 5-oxo-ETE induces a potent basophil migratory response, and LTB(4) elicits degranulation under certain conditions. [14]
  • Oxidative stress stimulates the synthesis of the eosinophil chemoattractant 5-oxo-ETE by inflammatory cells. [15]
  • 5-oxoETE induces human neutrophils to release some preincorporated [14C]arachidonic acid, while granulocyte colony-stimulating factors enhance the extent of this release. [16]
  • 5-Oxo-ETE elicits the infiltration of eosinophils and neutrophils into the skin of human beings in vivo after intradermal administration. [17]


Hormone function

  • homeostasis
    • ion flow control

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • hydroxy/hydroperoxyeicosatetraenoic acids


      Links to other resources

      KEGG C14732
      LIPID MAPS LMFA03060011
      LipidBank DFA8156