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Details for messenger / hormone: STC1

EndoNet ID: ENH01071

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Synonyms

  • Stanniocalcin-1
  • stanniocalcin 1
  • STC1

General information

  • The expression of STCs has been recognised as notably altered in a variety of cancers suggesting that they play a role in tumorigenesis [1]
  • STC-1 is sequestered by target cell subcellular organelles [2]
  • STC-1 uncouples oxidative phosphorylation [3]
  • STC-1 is also highly expressed in mouse ovary. [2]
  • STC-1 can modulate Ca2+ levels locally, as well as the activities of epithelial Ca2+ and PO4 transporters. [2]

Classification

Hormone function

  • homeostasis
    • ion flow control
    • development and growth
      • cancer / metastasis

      Chemical classification

      • hormone
        • genome-encoded
          • glycoprotein hormones family
            • stanniocalcin family

        Composition

        Sequence
        THEAEQNDS VSPRKSRVA AQNSAEVVR 
        CLNSALQVG CGAFACLEN STCDTDGMY 
        DICKSFLYS AAKFDTQGK AFVKESLKC 
        IANGVTSKV FLAIRRCST FQRMIAEVQ 
        EECYSKLNV CSIAKRNPE AITEVVQLP 
        NHFSNRYYN RLVRSLLEC DEDTVSTIR 
        DSLMEKIGP NMASLFHIL QTDHCAQTH 
        PRADFNRRR TNEPQKLKV LLRNLRGEE 
        DSPSHIKRT SHESA
        UniProt P52823

        Links to other resources

        UniProt P52823
        Ensembl ENST00000290271
        KEGG 6781
        • Anatomical structure: collecting_duct_of_renal_tubules

          • Kidney collecting duct principal cells are the main source of stanniocalcin-1 (STC-1) production and secretion. [4]

        Targets

        Cell
        No records found.
        Reference