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Details for messenger / hormone: STC-2

EndoNet ID: ENH01072

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Synonyms

  • Stanniocalcin-2
  • STC-2
  • stanniocalcin 2
  • stanniocalcin-related protein
  • STCRP

General information

  • Constitutive expression of STC2 in human breast cancer cells resulted in a significant impairment of cell proliferation [1]
  • Is a secreted, homodimeric glycoprotein that has been implicated in the physiology of phosphate regulation, metabolism, reproduction, stress response and development. [1]
  • STC2 expression is significantly elevated in a specific subset of breast tumours [1]
  • STC1 and STC2 are highly related. [1]

Classification

Hormone function

  • homeostasis
    • ion flow control
    • development and growth
      • cancer / metastasis

      Chemical classification

      • hormone
        • genome-encoded
          • glycoprotein hormones family
            • stanniocalcin family

        Composition

        Sequence 
        TDATNPPEG PQDRSSQQK GRLSLQNTA 
EIQHCLVNA GDVGCGVFE CFENNSCEI 
RGLHGICMT FLHNAGKFD AQGKSFIKD 
ALKCKAHAL RHRFGCISR KCPAIREMV 
SQLQRECYL KHDLCAAAQ ENTRVIVEM 
IHFKDLLLH EPYVDLVNL LLTCGEEVK 
EAITHSVQV QCEQNWGSL CSILSFCTS 
AIQKPPTAP PERQPQVDR TKLSRAHHG 
EAGHHLPEP SSRETGRGA KGERGSKSH 
PNAHARGRV GGLGAQGPS GSSEWEDEQ 
SEYSDIRR
        UniProt O76061

        Links to other resources

        UniProt O76061
        Ensembl ENST00000265087
        KEGG 8614

        • Anatomical structure: breast

          • STC2 expression represents a downstream target of E2, P4 and RA signalling pathways in human breast cancer cell lines. [1]

        Targets

        Cell
        No records found.
        Reference