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Details for messenger / hormone: TIP39

EndoNet ID: ENH01074

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Synonyms

  • TIP39
  • tuberoinfundibular peptide of 39 residues
  • parathyroid hormone 2
  • TIPF39
  • PTH2

General information

  • TIP39, unlike PTH on P1R, does not activate the IP signaling pathway in P1R or P2R. [1]
  • TIP39 from all species activates adenylyl cyclase and elevates intracellular calcium levels through PTH2R. [2]
  • TIP39 may exert its biological function via two different mechanisms, either by inhibiting the action of PTH and/or PTHrP on P1R, or by acting independently on P2R. [1]

Classification

Hormone function

Chemical classification

  • hormone
    • genome-encoded
      • parathyroid hormone family

    Composition

    Tuberoinfundibular peptide of 39 residues

    Sequence
    ASGVALPPV GVLSLRPPG RAWADPATP 
    RPRRSLALA DDAAFRERA RLLAALERR 
    HWLNSYMHK LLVLDAP
    UniProt Q96A98
    KEGG hsa:113091

    Links to other resources

    UniProt Q96A98
    Ensembl ENST00000270631
    KEGG hsa:113091
    • Anatomical structure: spinal_cord

    • Anatomical structure: kidney

      • Whether TIP39 acts as a competitor of P1R or as an activator for P2R in these tissues is unclear at present. [1]
      • Furthermore, there was evidence for TIP39 mRNA synthesis in fetal liver, kidney and heart.No response was detected in adult liver, lung, placenta and adrenal gland. [1]
    • Anatomical structure: brain

    • Anatomical structure: cerebellum

    • Anatomical structure: trachea

    Targets

    Cellparathyroid hormone 2 receptorPTHR1
    brain Present
    chondrocyte Present
    hematopoietic stem cell Present
    Influences
    • RANKL
    kidney Present
    Phenotypes
    • phosphate ion homeostasis
    • familial isolated hypoparathyroidism
    • Primary hyperparathyroidism
    Influences
    • calcitriol
    lung Present
    lymphocyte Present
    monocyte Present
    neutrophil granulocyte Present
    osteoblast Present
    Influences
    • RANKL
    • M-CSF
    • interleukin 6
    • amphiregulin
    osteoclast Present
    pancreas Present
    placenta Present
    stromal cell of bone marrow Present
    Influences
    • RANKL
    • M-CSF
    testis Present
    Reference