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Details for messenger / hormone: Alarin

EndoNet ID: ENH01077

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Synonyms

  • galanin-like peptide
  • Alarin
  • del/E3
  • galanin-like peptide Isoform 2

General information

Classification

Hormone function

Chemical classification

  • hormone
    • genome-encoded
      • galanin-family

    Composition

    Isoform 2

    • Cleavage of the signal peptide generates a peptide of 25 aa, termed alarin because of the N-terminal alanine and the C-terminal serine. Involved in ganglionic differentation in neuroblastic tumor tissues. Vasoactive peptide [1]
    Sequence 
    GRGGWTLNS AGYLLGPVL HLPQMGDQD 
GKRETALEI LDLWKAIDG LPYSHPPQP 
SKRNVMETF AKPEIGDLG MLSMKIPKE 
EDVLK
    UniProt Q9UBC7-2

    Links to other resources

    UniProt Q9UBC7-2
    Ensembl ENST00000357330
    KEGG hsa:85569

    • Anatomical structure: gangliocyte

      • the expression of a splice variant of the GALP gene, excluding exon 3, was observed in gangliocytes of human neuroblastic tumors [2]
      • Isoform 2 is found in ganglia of ganglianeuroma and ganglioneuroblastoma as well as in defferentiated tumor cells of neuroblastoma tissues. Not found in undifferented neuroplasts. is found in the skin, in pericystes coverin microvascular arterioles and venules on their abluminal surfaces. In larger vessels it is expressed n layers of smooth muscle cells. Isoform 2 is NOT detected in endothelial cells. [1]

    Targets

    Cell
    No records found.
    Reference