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Details for messenger / hormone: lysophosphatidic acid

EndoNet ID: ENH01113

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Synonyms

  • lysophosphatidic acid
  • LPA
  • lysoPA
  • 1-oleoyl lysophosphatidic acid
  • 1-oleoyl-sn-glycerol 3-phosphate

General information

  • LPA acts as a potent mitogen due to its activation of three high-affinity G-protein-coupled receptors called LPA1, LPA2, and LPA3 (also known as EDG2, EDG4, and EDG7) [1]
  • LPA stimulates the growth of fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes; furthermore, it promotes cellular tension and cell-surface fibronectin binding, which are important events in wound repair [1]
  • LPA receptor pathways are also activation of the small GTP-binding proteins Ras and Rho [1]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • not genome-encoded
          • phospholipid derivatives

        Links to other resources

        LipidBank PGP4003
        • Anatomical structure: platelet

          • LPA is produced in activated platelets. [2]
        • Anatomical structure: blood

        Targets

        CellLysophosphatidic acid receptor 1Lysophosphatidic acid receptor 2Lysophosphatidic acid receptor 3Lysophosphatidic acid receptor 4Lysophosphatidic acid receptor 5Lysophosphatidic acid receptor 6
        amygdaloid body Present
        astrocyte Present
        Phenotypes
        • astrocyte development
        Present
        Phenotypes
        • astrocyte differentiation
        brain Present
        Phenotypes
        • cerebral cortex development
        • positive regulation of cytoskeleton organization
        • regulation of actin filament bundle assembly
        • brain development
        • inhibition of adenylate cyclase activity by G-protein signaling pathway
        Present
        Present
        breast Present
        Phenotypes
        • breast cancer
        central nerve system element Present
        Phenotypes
        • schizophrenia
        colon Present
        Present
        Present
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        Present
        Present
        Influences
        • C-C motif chemokine 2
        • IL-1 beta
        • IL-8
        corpus luteum Present
        Phenotypes
        • negative regulation of progesterone biosynthetic process
        dendritic cell in lymphoid tissues Present
        Phenotypes
        • dendritic cell chemotaxis
        digestive system Present
        Phenotypes
        • gastrointestinal cancer
        Present
        Phenotypes
        • gastrointestinal cancer
        fetal brain Present
        Phenotypes
        • brain development
        Present
        Phenotypes
        • brain development
        fibroblast Present
        Phenotypes
        • wound healing
        frontal lobe Present
        hair follicle Present
        Present
        Present
        Present
        Phenotypes
        • autosomal recessive woolly hair
        heart Present
        Present
        Present
        Present
        hippocampus Present
        Phenotypes
        • positive regulation of neuron differentiation
        Present
        kidney Present
        Phenotypes
        • fibrosis
        Present
        Present
        Present
        leukocyte Present
        liver Present
        lung Present
        Phenotypes
        • pulmonary fibrosis
        Present
        Present
        Present
        lymphocyte Present
        Phenotypes
        • regulation of immune response
        microglial cell in central nervous system Present
        Phenotypes
        • membrane hyperpolarization
        • positive regulation of chemokinesis
        • membrane ruffling
        • positive regulation of cytokine production
        • regulation of glia cell proliferation
        Present
        Phenotypes
        • regulation of inflammatory response
        microvascularendothelial cell Present
        muscle Present
        nerve Present
        Phenotypes
        • sensory perception of pain
        neuron Present
        Phenotypes
        • negative regulation of neuron projection development
        • regulation of cell proliferation
        Present
        Phenotypes
        • negative regulation of neuron projection development
        Present
        Phenotypes
        • neuron projection morphogenesis
        oligodendrocyte Present
        Phenotypes
        • myelin formation in the central nervous system
        • cell maturation
        Present
        osteoblast Present
        Phenotypes
        • skeletal system development
        ovary Present
        Phenotypes
        • Ovarian cancer
        Present
        Phenotypes
        • Ovarian cancer
        • Ovarian cancer
        Present
        Phenotypes
        • Ovarian cancer
        • Ovarian cancer
        Present
        pancreas Present
        Present
        Present
        Present
        peripheral blood leukocytes Present
        Present
        placenta Present
        Present
        platelet Present
        Phenotypes
        • atherosclerosis
        Present
        Phenotypes
        • atherosclerosis
        preadipocyte Present
        Phenotypes
        • negative regulation of fat cell differentiation
        • positive regulation of cell motility
        • positive regulation of fat cell proliferation
        • positive regulation of glucose import
        prostate Present
        Present
        Present
        Present
        Schwann cell Present
        Phenotypes
        • regulation of myelination
        • regulation of actin cytoskeleton organization
        • negative regulation of glial cell apoptosis
        • myelin formation in the peripheral nervous system
        Present
        Phenotypes
        • myelin formation in the peripheral nervous system
        • myelin formation in the peripheral nervous system
        • regulation of myelination
        skeleton muscle Present
        Present
        skin Present
        small intestine Present
        Present
        Present
        Present
        smooth muscle cell Present
        Phenotypes
        • negative regulation of smooth muscle cell migration
        • smooth muscle cell dedifferentiation
        • smooth muscle cell migration
        • regulation of vascular smooth muscle cell proliferation
        • positive regulation of smooth muscle proliferation
        Present
        Phenotypes
        • positive regulation of smooth muscle cell migration
        spleen Present
        Present
        Present
        Present
        stomach Present
        Present
        Present
        T-lymphocyte Present
        Phenotypes
        • regulation of T cell chemotaxis
        • positive regulation of interleukin-2 production
        • positive regulation of interleukin-13 production
        • positive regulation of activated T cell proliferation
        Present
        Phenotypes
        • negative regulation of interleukin-2 production
        • regulation of T cell chemotaxis
        testis Present
        Present
        Present
        Present
        thymus Present
        Present
        Present
        umbilical vein endothelial cells Present
        Phenotypes
        • positive regulation of cell death
        uterus Present
        Phenotypes
        • embryo implantation
        vascularendothelial cell Present
        Phenotypes
        • positive regulation of angiogenesis
        • cell maturation
        • induction of cytokine expression
        • negative regulation of apoptosis
        Present
        Present
        Phenotypes
        • negative regulation of apoptosis
        white matter Present
        Reference