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Details for messenger / hormone: GLP-1

EndoNet ID: ENH01121

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Synonyms

  • GLP-1
  • glucagon-like peptide 1
  • GLP1
  • Glucagon

General information

  • OXM and GLP-1 are products of the preproglucagon gene, which is expressed in the CNS, the L cells of the small intestine, and the pancreas. Preproglucagon is cleaved by prohormone convertase 1 and 2 into different products depending on the tissue. [1]
  • Increasing plasma levels of GLP-1 and OXM result in postprandial satiety. It also inhibits gastric acid secretion and motility. [1]
  • OXM and GLP-1 promotes meal-induced insulin secretion. [1]
  • By binding to its receptors located on beta-cells, GLP-1 synergizes with glucose to induce insulin secretion. [2]
  • GLP-1 is a gut peptide that, together with its receptor, GLP-1R, is expressed in the brain. [3]
  • Glucagon-like peptide-1 is a fragment of proglucagon secreted by intestinal L-cells, with potent glucose-dependent insulin secretory effects. It also suppresses gastric acid secretion in the stomach. [4]
  • GLP-1 inhibits glucagon secretion from alpha cells after binding to its specific receptors. [5]
  • GLP-1 is released from intestinal L cells on meal ingestion. In a glucose-dependent manner GLP-1 stimulates insulin secretion and decreases glucagon secretion, reduces gastric emptying, and promotes fullness/satiety. [6]
  • GLP-1 secretion lead to lowered hyperglycemia and body weight in type 2 diabetics. [6]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • glucagon family

      Composition

      Sequence
      HDEFERHAE GTFTSDVSS YLEGQAAKE 
      FIAWLVKGR G
      UniProt P01275

      Links to other resources

      UniProt P01275
      Ensembl ENST00000418842
      KEGG hsa:2641
      • Anatomical structure: enteroendocrine_cell_of_gastrointestinal_tract

      • Anatomical structure: nuclei_of_solitary_tract

      • Anatomical structure: APUD_amine_precursor_uptake_and_decarboxylation_cell

        • GLP-1 is released from intestinal L cells on meal ingestion [6]
      • Anatomical structure: digestive_system

        • Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is expressed in the brain. [3]

      Targets

      CellGLP-1R
      alpha cell of islet of Langerhans Present
      Influences
      • glucagon
      beta cell of islet of Langerhans Present
      Phenotypes
      • regulation of glucose homeostasis
      • positive regulation of anti-apoptosis
      • pancreatc B cell differentiation
      • inhibition of gastric emptying
      Influences
      • insulin
      hypothalamus Present
      Phenotypes
      • reduction of food intake
      pancreas Present
      pancreatic islets Present
      proximal tubule of nephron Present
      Phenotypes
      • reduction of sodium re-absorption
      Reference