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Details for messenger / hormone: proprotein convertase subtilisin/kexin type 9

EndoNet ID: ENH01122

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Synonyms

  • proprotein convertase subtilisin/kexin type 9
  • PCSK9
  • neural apoptosis-regulated convertase 1
  • subtilisin/kexin-like protease PC9
  • proprotein convertase 9

General information

  • PCSK9 is the ninth member of a family of secretory serine proteinases known as the proprotein convertases. [1]
  • It induces an enhanced cellular degradation of the low density lipoprotein receptor (LDLR) in endosomes-lysosomes. [2]
  • PCSK9 binds to a ∼33-kDa protein identified as annexin A2 (AnxA2) but not to the closely related annexin A1. [3]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    Links to other resources

    UniProt Q8NBP7
    Ensembl ENST00000452118
    KEGG hsa:255738

      Targets

      CellLDL-R
      hepatocyte Present
      Influences
      • ↓ apo B-48
      • ↓ apo B-100
      Reference