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Details for messenger / hormone: insulin receptor substrate 1

EndoNet ID: ENH01125

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  • insulin receptor substrate 1
  • IRS1

General information

  • May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
  • Function: binds to both IGF-1R and insulin receptor. Activates thus Pi3K and sends a strong mitogenic, anti-apoptotic and anti-differentiation signal. [1]


Hormone function

  • development and growth
    • growth inhibition
      • apoptosis

      Chemical classification

      Links to other resources

      UniProt P35568
      Ensembl ENST00000305123
      KEGG hsa:3667
      • Anatomical structure: beta_cell_of_islet_of_Langerhans

        Influenced by:

        • insulin receptor
          in beta_cell_of_islet_of_Langerhans
          • There might be a direct link between the insulin receptor signaling pathway and the Ca2+ -dependent pathways regulating insulin secretion of b-cells. During regulated insulin secretion, released insulin binds the b-cell insulin receptor and activates IRS-1, thus further increasing cytosolic Ca2+ by reducing Ca2+ uptake. [2]


      No records found.