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Details for messenger / hormone: pigment epithelium-derived factor

EndoNet ID: ENH01126

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Synonyms

  • EPC-1
  • Serpin-F1
  • pigment epithelium-derived factor
  • PEDF
  • cell proliferation-inducing gene 35 protein
  • serpin F1

General information

  • Function: Inhibits blood vessel formation in eye by inducing apoptosis in dividing epithelial cells. Affects survival and differentiation of neurons. [1]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    Links to other resources

    UniProt P36955
    Ensembl ENST00000254722
    KEGG hsa:5176
    • Anatomical structure: melanocyte

    • Anatomical structure: hippocampus

      Influenced by:

      • GPR39 protein
        in hippocampus
        • GPR39 overexpression leads to increased secretion of the cytoprotective pigment epithelium-dereived growth factor (PEDF). [2]

    Targets

    CellVascular endothelial growth factor receptor 2
    bone marrow Present
    Phenotypes
    • angiogenesis
    continuous vascular endothelial cell of blood vessels and lymphatics Present
    Influences
    • VEGF-165
    microvascularendothelial cell Present
    Influences
    • von Willebrand factor
    Müllers radial cell of retina Present
    Phenotypes
    • regulation of neural retina development
    sinusoidal endothelial cell Present
    Phenotypes
    • regulation of endothelial cell differentiation
    Reference