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Details for messenger / hormone: Sphingosylphosphorylcholine

EndoNet ID: ENH01133

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Synonyms

  • Sphingosylphosphorylcholine
  • SPC

General information

  • Function: can act as proinflammatory mediator in cerebral arteries. Also able to constrict cerebral arteries. [1]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
    • immune response
      • activation

      Chemical classification

      Links to other resources

        Targets

        CellG-protein coupled receptor 12G-protein coupled receptor 4Ovarian cancer G-protein coupled receptor 1Probable G-protein coupled receptor 132Sphingosine 1-phosphate receptor 1Sphingosine 1-phosphate receptor 2Sphingosine 1-phosphate receptor 3Sphingosine 1-phosphate receptor 4Sphingosine 1-phosphate receptor 5
        adipose tissue Present
        Present
        Phenotypes
        • promotion of mesenchymal cell differentiation
        adrenal gland Present
        Influences
        • aldosterone
        aorta Present
        Phenotypes
        • positive regulation of angiogenesis
        appendix Present
        B-lymphocyte Present
        Phenotypes
        • regulation of leukocyte migration
        Present
        bone Present
        bone marrow Present
        Present
        brain Present
        Phenotypes
        • positive regulation of neuron differentiation
        Present
        Present
        Phenotypes
        • positive regulation of neuron projection development
        Present
        Phenotypes
        • positive regulation of neurogenesis
        Present
        Phenotypes
        • neuron projection morphogenesis
        Present
        Present
        Phenotypes
        • proliferation of radial glia cells
        • astrocyte development
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        Phenotypes
        • positive regulation of cell growth
        Present
        Phenotypes
        • cell-cell junction organization
        • vasculogenesis
        • positive regulation of endothelial cell migration
        • regulation of endothelial cell differentiation
        corpus callosum Present
        dendritic cell in lymphoid tissues Present
        Phenotypes
        • regulation of innate immune response
        Present
        Phenotypes
        • dendritic cell chemotaxis
        Present
        Present
        Phenotypes
        • dendritic cell chemotaxis
        • positive regulation of endocytosis
        • positive regulation of interleukin-1 beta production
        Present
        Phenotypes
        • regulation of T cell differentiation
        • regulation of leukocyte migration
        • dendritic cell chemotaxis
        Present
        Phenotypes
        • dendritic cell chemotaxis
        eosinophil granulocyte Present
        Present
        Present
        epithelial cell Present
        fibroblast Present
        heart Present
        Present
        Present
        Present
        Present
        Phenotypes
        • heart development
        Present
        immune system Present
        Present
        Present
        Phenotypes
        • positive regulation of chemotaxis
        • negative regulation of chemotaxis
        • regulation of leukocyte migration
        • regulation of leukocyte migration
        Present
        Present
        Present
        Present
        keratinocyte Present
        Phenotypes
        • positive regulation of cell growth
        Present
        Present
        Present
        Present
        Present
        kidney Present
        Present
        Present
        Present
        Present
        killer cell Present
        Phenotypes
        • positive regulation of leukocyte migration
        killer T cell Present
        Phenotypes
        • positive regulation of chemotaxis
        Present
        Phenotypes
        • positive regulation of chemotaxis
        Present
        Phenotypes
        • positive regulation of chemotaxis
        leukocyte Present
        liver Present
        Present
        Present
        Phenotypes
        • hepatic stellate cell migration
        Present
        Present
        Phenotypes
        • hepatic stellate cell migration
        Present
        lung Present
        Present
        Present
        Present
        Influences
        • interleukin 6
        Present
        Present
        Phenotypes
        • adherens junction assembly
        Present
        Present
        lymph node Present
        Present
        Phenotypes
        • lymphocyte homeostasis
        Present
        lymphocyte Present
        Phenotypes
        • regulation of actin cytoskeleton organization
        • lymphocyte homeostasis
        Present
        Phenotypes
        • regulation of lymphocyte proliferation
        • regulation of leukocyte migration
        Present
        Phenotypes
        • regulation of leukocyte migration
        Present
        Phenotypes
        • LGL leukemia
        macrophage Present
        Phenotypes
        • atherosclerosis
        Present
        Phenotypes
        • regulation of innate immune response
        • atherosclerosis
        Present
        Phenotypes
        • negative regulation of cytokine production
        Present
        Phenotypes
        • negative regulation of cytokine production
        mast cell Present
        Phenotypes
        • positive regulation of mast cell chemotaxis
        Present
        Phenotypes
        • negative regulation of mast cell degranulation
        melanocyte Present
        neuron Present
        Phenotypes
        • regulation of membrane potential
        • negative regulation of neuron projection development
        oligodendrocyte Present
        Phenotypes
        • regulation of myelination
        osteoblast Present
        Present
        Phenotypes
        • positive regulation of osteoblast proliferation
        Present
        ovary Present
        pancreas Present
        peripheral blood leukocytes Present
        Present
        peripheral blood lymphocytes Present
        placenta Present
        Present
        Present
        skeleton muscle Present
        Present
        skin Present
        small intestine Present
        Present
        smooth muscle cell Present
        Phenotypes
        • positive regulation of cell growth
        Present
        Phenotypes
        • positive regulation of smooth muscle cell migration
        • heart development
        • positive regulation of angiogenesis
        • regulation of inflammatory response
        Present
        Phenotypes
        • positive regulation of cell proliferation
        Present
        Phenotypes
        • vasoconstriction
        • regulation of inflammatory response
        spleen Present
        Present
        Phenotypes
        • lymphocyte homeostasis
        Present
        Present
        Present
        Present
        Present
        stomach Present
        T-lymphocyte Present
        Phenotypes
        • Systemic lupus erythematosus
        • modulation of T cell response
        • regulation of T cell activation
        Present
        Phenotypes
        • cell maturation
        • negative regulation of interferon-gamma production
        • positive regulation of interleukin-4 production
        • regulation of T cell proliferation
        • T cell differentiation during immune response
        • positive regulation of leukocyte migration
        • regulation of leukocyte migration
        Present
        Phenotypes
        • negative regulation of T cell apoptosis
        Present
        Phenotypes
        • negative regulation of T cell apoptosis
        Present
        Phenotypes
        • negative regulation of interferon-gamma and interleukin-4 production
        • positive regulation of interleukin-10 production
        • positive regulation of leukocyte migration
        testis Present
        Present
        Present
        Phenotypes
        • reproduction
        thymus Present
        Present
        Present
        Phenotypes
        • positive regulation of chemotaxis
        Present
        Present
        thyroid gland Present
        Phenotypes
        • regulation of cellular calcium homeostasis
        umbilical vein endothelial cells Present
        Phenotypes
        • venous endothelial cell differentiation
        vascularendothelial cell Present
        Phenotypes
        • regulation of cardiovascular system
        • positive regulation of blood vessel endothelial cell migration
        • positive regulation of endothelial cell proliferation
        • positive regulation of angiogenesis
        • adherens junction assembly
        Present
        Phenotypes
        • positive regulation of endothelial cell proliferation
        • positive regulation of blood vessel endothelial cell migration
        • adherens junction assembly
        white matter Present
        Phenotypes
        • regulation of oligodendrocyte differentiation
        Reference