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Details for messenger / hormone: LIGHT

EndoNet ID: ENH01149

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Synonyms

  • HVEML
  • LIGHT
  • CD258
  • TNFSF14
  • HVEM-L
  • herpesvirus entry mediator ligand
  • tumor necrosis factor ligand superfamily member 14
  • herpes virus entry mediator ligand

General information

  • LIGHT is a tumor necrosis factor (TNF) ligand superfamily member, which binds two known cellular receptors, lymphotoxin-β receptor (LTβR) and the herpesvirus entry mediator (HveA). [1]
  • LIGHT is a homotrimer that activates proapoptotic and integrin-inducing pathways. [1]

Classification

Hormone function

Chemical classification

  • hormone
    • genome-encoded
      • cytokines
        • TNF family

    Links to other resources

    UniProt O43557
    Ensembl ENST00000326176
    KEGG hsa:8740

      Targets

      CellHVEMLTBR
      blood myeloid cell Present
      stromal cell Present
      Phenotypes
      • formation of secondary lymphoid tissue
      Reference