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hypothalamic-pituitary-growth hormone axis

The hypothalamic-pituitary-growth hormone axis gives rise to numerous anabolic processes including the increase of height, the increase of muscle mass, and the growth of all organs except for the brain. Main components are the hypothalamus, the anterior pituitary, and the liver.

  • hypothalamus GHRH [36] [secr.]
    • "" -1 liver IGF-1 [42] [secr.]
  • GHRH pituitary gland of diencephalon [37] [binding] []
    • "" 1 hypothalamus GHRH [36] [secr.]
  • hypothalamus somatostatin [38] [secr.]
    • "" 1 liver IGF-1 [42] [secr.]
  • somatostatin pituitary gland of diencephalon [39] [binding] []
    • "" 1 hypothalamus somatostatin [38] [secr.]
  • pituitary gland of diencephalon GH [40] [secr.]
    • "" -1 somatostatin pituitary gland of diencephalon [39] [binding] []
    • "" 1 GHRH pituitary gland of diencephalon [37] [binding] []
    • "" -1 liver IGF-1 [42] [secr.]
    • "" 1 stomach ghrelin [119] [secr.]
  • GH liver [41] [binding] []
    • "" 1 pituitary gland of diencephalon GH [40] [secr.]
  • liver IGF-1 [42] [secr.]
    • "" 1 GH liver [41] [binding] []
  • liver IGFBP-1 isoform a [43] [secr.]
    • "" 1 GH liver [41] [binding] []
  • lipid digestion in adipose tissue [44] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]
  • skeletal muscle growth in muscle [45] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]
  • endochondral ossification in bone [46] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]
  • amino acid uptake in [47] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]