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renin-angiotensin-aldosterone system

The renin-angiotensin-aldosterone system (RAAS) involves the liver, the kidney, the lung, and the blood system. Main function is the regulation of blood pressure in response to changes in the fluid balance.
encluster0livercluster1adrenal_cortexcluster2kidneycluster3lungcluster4bloodsec578h82Secretion angiotensinogenbind14h171Binding angiotensin Isec578h82->bind14h171angiotensinogenbind7h5Binding aldosteronephen90blood pressure increasebind7h5->phen90sec63h612Secretion reninsec63h612->bind14h171reninbind74h924Binding sACE2bind14h97Binding angiotensin IIbind74h924->bind14h97sACE2bind14h171->bind14h97angiotensin Ibind14h97->bind7h5angiotensin IIbind14h97->phen90stim18decrease in renal perfusionstim18->sec63h612phen90->sec63h612

  • liver angiotensinogen [137] [secr.]
    • kidney renin [141] [secr.]
      • "" 1 decrease in renal perfusion in [140] [sti.]
      • "" -1 blood pressure increase in [143] [phe.]
    • angiotensin I blood [138] [binding] []
      • "" 1 kidney renin [141] [secr.]
      • "" 1 liver angiotensinogen [137] [secr.]
    • angiotensin II blood [139] [binding] []
      • "" 1 angiotensin I blood [138] [binding] []
      • "" 1 sACE2 lung [142] [binding] []
    • blood pressure increase in [143] [phe.]
      • "" 1 angiotensin II blood [139] [binding] []
      • "" 1 aldosterone adrenal cortex [163] [binding] []
    • aldosterone adrenal cortex [163] [binding] []
      • "" 1 angiotensin II blood [139] [binding] []