Status
Please wait ...

hypothalamic-pituitary-thyroid axis

The serum levels of the thyroid hormones T3 and T4 are tightly controlled by the hypothalamic-hypophyseal-thyroid (HPT) axis that depends on the hypothalamus, the anterior pituitary, and the thyroid gland. Main function is the regulation of metabolism under physiological conditions.
encluster0pituitary_gland_of_diencephaloncluster1thyroid_glandcluster2hypothalamussec53h121Secretion TSHbind145h121Binding TSHsec53h121->bind145h121TSHbind53h122Binding TRHbind53h122->sec53h121TRHbind53h56Binding T3bind53h56->sec53h121T3bind53h123Binding T4bind53h123->sec53h121T4sec145h56Secretion T3sec145h123Secretion T4sec145h56->bind53h56T3phen691increase of metabolic ratesec145h56->phen691T3phen692calorigenic effectsec145h56->phen692T3sec145h123->bind53h123T4sec145h123->phen691T4sec145h123->phen692T4bind145h121->sec145h56TSHbind145h121->sec145h123TSHsec361h122Secretion TRHsec361h122->bind53h122TRH

  • hypothalamus TRH [26] [secr.]
    • TRH pituitary gland of diencephalon [27] [binding] []
      • "" 1 hypothalamus TRH [26] [secr.]
    • pituitary gland of diencephalon TSH [28] [secr.]
      • "" 1 TRH pituitary gland of diencephalon [27] [binding] []
      • "" -1 T3 pituitary gland of diencephalon [34] [binding] []
      • "" -1 T4 pituitary gland of diencephalon [35] [binding] []
    • TSH thyroid gland [29] [binding] []
      • "" 1 pituitary gland of diencephalon TSH [28] [secr.]
    • thyroid gland T3 [30] [secr.]
      • "" 1 TSH thyroid gland [29] [binding] []
    • thyroid gland T4 [31] [secr.]
      • "" 1 TSH thyroid gland [29] [binding] []
    • increase of metabolic rate in [32] [phe.]
      • "" 1 thyroid gland T4 [31] [secr.]
      • "" 1 thyroid gland T3 [30] [secr.]
    • calorigenic effect in [33] [phe.]
      • "" 1 thyroid gland T4 [31] [secr.]
      • "" 1 thyroid gland T3 [30] [secr.]
    • T3 pituitary gland of diencephalon [34] [binding] []
      • "" 1 thyroid gland T3 [30] [secr.]
    • T4 pituitary gland of diencephalon [35] [binding] []
      • "" 1 thyroid gland T4 [31] [secr.]