Status
Please wait ...

hypothalamic-pituitary-growth hormone axis

The hypothalamic-pituitary-growth hormone axis gives rise to numerous anabolic processes including the increase of height, the increase of muscle mass, and the growth of all organs except for the brain. Main components are the hypothalamus, the anterior pituitary, and the liver.
encluster0livercluster1pituitary_gland_of_diencephaloncluster2stomachcluster3hypothalamussec578h31Secretion IGF-1sec578h859Secretion IGFBP-1 isoform asec53h117Secretion GHsec578h31->sec53h117IGF-1sec361h78Secretion GHRHsec578h31->sec361h78IGF-1sec361h124Secretion somatostatinsec578h31->sec361h124IGF-1phen26c5lipid digestion in adipose tissuesec578h31->phen26c5IGF-1phen693c171skeletal muscle growth in musclesec578h31->phen693c171IGF-1phen664c382endochondral ossification in bonesec578h31->phen664c382IGF-1phen694amino acid uptakesec578h31->phen694IGF-1sec578h859->phen26c5IGFBP-1 isoform asec578h859->phen693c171IGFBP-1 isoform asec578h859->phen664c382IGFBP-1 isoform asec578h859->phen694IGFBP-1 isoform abind578h117Binding GHbind578h117->sec578h31GHbind578h117->sec578h859GHsec53h117->bind578h117GHbind53h78Binding GHRHbind53h78->sec53h117GHRHbind53h124Binding somatostatinbind53h124->sec53h117somatostatinsec132h127Secretion ghrelinsec132h127->sec53h117ghrelinsec361h78->bind53h78GHRHsec361h124->bind53h124somatostatin

  • hypothalamus GHRH [36] [secr.]
    • "" -1 liver IGF-1 [42] [secr.]
  • GHRH pituitary gland of diencephalon [37] [binding] []
    • "" 1 hypothalamus GHRH [36] [secr.]
  • hypothalamus somatostatin [38] [secr.]
    • "" 1 liver IGF-1 [42] [secr.]
  • somatostatin pituitary gland of diencephalon [39] [binding] []
    • "" 1 hypothalamus somatostatin [38] [secr.]
  • pituitary gland of diencephalon GH [40] [secr.]
    • "" -1 somatostatin pituitary gland of diencephalon [39] [binding] []
    • "" 1 GHRH pituitary gland of diencephalon [37] [binding] []
    • "" -1 liver IGF-1 [42] [secr.]
    • "" 1 stomach ghrelin [119] [secr.]
  • GH liver [41] [binding] []
    • "" 1 pituitary gland of diencephalon GH [40] [secr.]
  • liver IGF-1 [42] [secr.]
    • "" 1 GH liver [41] [binding] []
  • liver IGFBP-1 isoform a [43] [secr.]
    • "" 1 GH liver [41] [binding] []
  • lipid digestion in adipose tissue [44] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]
  • skeletal muscle growth in muscle [45] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]
  • endochondral ossification in bone [46] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]
  • amino acid uptake in [47] [phe.]
    • "" 1 liver IGF-1 [42] [secr.]
    • "" 1 liver IGFBP-1 isoform a [43] [secr.]