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Details for phenotype: positive regulation of appetite

EndoNet ID: ENP00002

Name

positive regulation of appetite

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68001069

Phenotype triggers

  • normal activity of GHS-R1
    in arcuate_nucleus_of_hypothalamus
    • Ghrelin transduces an appetite-stimulatory signal from peripheral tissues to central nervous system [1]
    • Ghrelin acts in harmony with appetite-stimulating signals from peripheral organs and stimulate food intake [2]
  • normal activity of NPY1-R
    in arcuate_nucleus_of_hypothalamus
    • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [3]
  • normal activity of NPY2-R
    in arcuate_nucleus_of_hypothalamus
    • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [3]
  • normal activity of NPY5-R
    in arcuate_nucleus_of_hypothalamus
    • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [3]
  • normal activity of NPY6-R
    in arcuate_nucleus_of_hypothalamus
    • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [3]
  • normal activity of GHS-R1
    in hypothalamus
    • High ghrelin levels lead on the level of the hypothlamus to increased food intake [4]
  • normal activity of GHSR
    in arcuate_nucleus_of_hypothalamus
    • Ghrelin has been shown to exert its orexigenic effect by activating NPY/Agrp neurons while inhibiting the anorexigenic POMC neurons.However, similar to leptin, ghrelin also acts in other brain regions to modulate food intake [5]
    • Ghrelin binds to neurons in the ventral tegmental area (VTA), where it increases dopamine neuronal activity and dopamine turnover in the nucleus accumbens. Direct VTA administration of ghrelin was sufficient to induce food intake, while the blockage of ghrelin's action in the VTA by infusion of a ghrelin antagonist blocked the orexigenic effect of circulating ghrelin. [6]
  • normal activity of NPY4-R
    in arcuate_nucleus_of_hypothalamus
    • The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake. [3]
Reference