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Statistic
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Details for phenotype: positive regulation of appetite
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EndoNet ID: ENP00002
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Name
positive regulation of appetite
General information
This phenotype is not pathologic
Links to other resources
GO
positive regulation of appetite
MeSH term
68001069
Phenotype triggers
normal activity of
GHS-R1
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
Ghrelin transduces an appetite-stimulatory signal from peripheral tissues to central nervous system
[1]
Ghrelin acts in harmony with appetite-stimulating signals from peripheral organs and stimulate food intake
[2]
normal activity of
NPY1-R
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake.
[3]
normal activity of
NPY2-R
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake.
[3]
normal activity of
NPY5-R
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake.
[3]
normal activity of
NPY6-R
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake.
[3]
normal activity of
GHS-R1
ui-button
in
hypothalamus
ui-button
High ghrelin levels lead on the level of the hypothlamus to increased food intake
[4]
normal activity of
GHSR
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
Ghrelin has been shown to exert its orexigenic effect by activating NPY/Agrp neurons while inhibiting the anorexigenic POMC neurons.However, similar to leptin, ghrelin also acts in other brain regions to modulate food intake
[5]
Ghrelin binds to neurons in the ventral tegmental area (VTA), where it increases dopamine neuronal activity and dopamine turnover in the nucleus accumbens. Direct VTA administration of ghrelin was sufficient to induce food intake, while the blockage of ghrelin's action in the VTA by infusion of a ghrelin antagonist blocked the orexigenic effect of circulating ghrelin.
[6]
normal activity of
NPY4-R
ui-button
in
arcuate_nucleus_of_hypothalamus
ui-button
The injection of neuropeptide-Y into either the cerebral ventricles or directly into the hypothalamic paraventricular nucleus promoted a robust increase in food intake.
[3]
Reference