Details for phenotype: sensory perception of pain

EndoNet ID: ENP00009

Name

sensory perception of pain

This phenotype is not pathologic

GO	sensory perception of pain
MeSH term	68010146

normal activity of VPAC1
in brain
- Vasoactive intestinal peptide participatse in pain perception. [1]
normal activity of Lysophosphatidic acid receptor 1
in nerve
- Furthermore, Lpar1-deficient mice are resistant to neuropathic pain induced by partial sciatic nerve ligation. [2]
- It was shown that LPA is able to initiate neuropathic pain in the peripheral nervous system, which occurs through the activation of LPA1 and subsequent release of the pronociceptive factor substance P. [3]
normal activity of SPR
in corpus_striatum
- SP modulates pain centrally and peripherally. Receptor expression has high density in the striatum, amygdala and dorsolaterla prefrontal cortex [4]
normal activity of Transient receptor potential cation channel subfamily V member 1
in spinal_cord
- VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia. [5]
- Inflammatory mediators augment nociceptor thermal responsiveness, in part, through their actions on VR1. [5]
normal activity of Transient receptor potential cation channel subfamily V member 1
in dorsal_root_ganglion
- VR1 is essential for the development of sensitization to thermal stimuli during inflammation but not for the normal sensation of noxious heat. [6]

Reference