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Statistic
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Details for phenotype: sensory perception of pain
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EndoNet ID: ENP00009
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Name
sensory perception of pain
General information
This phenotype is not pathologic
Links to other resources
GO
sensory perception of pain
MeSH term
68010146
Phenotype triggers
normal activity of
VPAC1
ui-button
in
brain
ui-button
Vasoactive intestinal peptide participatse in pain perception.
[1]
normal activity of
Lysophosphatidic acid receptor 1
ui-button
in
nerve
ui-button
Furthermore, Lpar1-deficient mice are resistant to neuropathic pain induced by partial sciatic nerve ligation.
[2]
It was shown that LPA is able to initiate neuropathic pain in the peripheral nervous system, which occurs through the activation of LPA1 and subsequent release of the pronociceptive factor substance P.
[3]
normal activity of
SPR
ui-button
in
corpus_striatum
ui-button
SP modulates pain centrally and peripherally. Receptor expression has high density in the striatum, amygdala and dorsolaterla prefrontal cortex
[4]
normal activity of
Transient receptor potential cation channel subfamily V member 1
ui-button
in
spinal_cord
ui-button
VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia.
[5]
Inflammatory mediators augment nociceptor thermal responsiveness, in part, through their actions on VR1.
[5]
normal activity of
Transient receptor potential cation channel subfamily V member 1
ui-button
in
dorsal_root_ganglion
ui-button
VR1 is essential for the development of sensitization to thermal stimuli during inflammation but not for the normal sensation of noxious heat.
[6]
Reference