Details for phenotype: vasculogenesis

EndoNet ID: ENP00012

Name

vasculogenesis

This phenotype is not pathologic

GO	vasculogenesis
MeSH term	68001808

normal activity of Vascular endothelial growth factor receptor 1
in vascularendothelial_cell
- VEGF is a crucial regulator of vasculogenesis. [1]
normal activity of Sphingosine 1-phosphate receptor 1
in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
- S1PR1 has an important role in regulating endothelial-cell organization during development. [2]
normal activity of ER-beta
in corpus_luteum
- The corpus luteum is associated with angiogenesis followed by vascular regression. As estradiol is produced by granulosa-lutein cells of the corpus luteum, with receptors on endothelial cells, it may have potential effects on endothelial cell function. It is not known whether estradiol has any direct effects, but it is notable that molecules based on estrogen have been shown to have anti-angiogenic properties. Therfore, estradiol may have effects on the luteal vasculature. [3]
normal activity of EPHB4
in vascularendothelial_cell
- Recently, ephrinB2 has been shown to be required for the remodeling of the embryonic vascular system. [4]
- Because of its exclusive expression on arteries and the complementary expression of one of its cognate receptors, EphB4, on veins, it was suggested that ephrinB2 acts both as a ligand and as a receptor for EphB4. [4]

Reference