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Statistic
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Details for phenotype: vasculogenesis
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EndoNet ID: ENP00012
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Name
vasculogenesis
General information
This phenotype is not pathologic
Links to other resources
GO
vasculogenesis
MeSH term
68001808
Phenotype triggers
normal activity of
Vascular endothelial growth factor receptor 1
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in
vascularendothelial_cell
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VEGF is a crucial regulator of vasculogenesis.
[1]
normal activity of
Sphingosine 1-phosphate receptor 1
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in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
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S1PR1 has an important role in regulating endothelial-cell organization during development.
[2]
normal activity of
ER-beta
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in
corpus_luteum
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The corpus luteum is associated with angiogenesis followed by vascular regression. As estradiol is produced by granulosa-lutein cells of the corpus luteum, with receptors on endothelial cells, it may have potential effects on endothelial cell function. It is not known whether estradiol has any direct effects, but it is notable that molecules based on estrogen have been shown to have anti-angiogenic properties. Therfore, estradiol may have effects on the luteal vasculature.
[3]
normal activity of
EPHB4
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in
vascularendothelial_cell
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Recently, ephrinB2 has been shown to be required for the remodeling of the embryonic vascular system.
[4]
Because of its exclusive expression on arteries and the complementary expression of one of its cognate receptors, EphB4, on veins, it was suggested that ephrinB2 acts both as a ligand and as a receptor for EphB4.
[4]
Reference