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Details for phenotype: regulation of angiogenesis

EndoNet ID: ENP00013


regulation of angiogenesis

General information

This phenotype is not pathologic

Links to other resources


Phenotype triggers

  • normal activity of Vascular endothelial growth factor receptor 1
    in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
    • VEGF is a crucial regulator of angiogenesis.
  • normal activity of neuropilin-2
    in vascularendothelial_cell
    • neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis [1]
  • normal activity of ADAM17
    in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
    • ADAM-17 regulates angiogenesis via its effects on the proliferation of endothelial cells, network formation, invasion and activation of MMP-2. [2]
  • normal activity of basigin
    in blood_vessel
    • Basigning regulates angiogenesis by increasing protease production ass well as by upregulation of hypoxia-inducible factor-2alpha, VEGFR2, and the soluble forms of VEGF. [3]
  • more activity (high ligand concentration, overexpression) of angiotensin II type 1 receptor
    in granulosa_cell
    • In conjunction with the angiotensin II type 1 receptor, angiotensin II mediates angiogenesis in the ovary via secretion of vascular endothelial growth factor. [4]