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Statistic
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Details for phenotype: regulation of angiogenesis
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EndoNet ID: ENP00013
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Name
regulation of angiogenesis
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of angiogenesis
Phenotype triggers
normal activity of
Vascular endothelial growth factor receptor 1
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in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
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VEGF is a crucial regulator of angiogenesis.
normal activity of
neuropilin-2
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in
vascularendothelial_cell
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neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis
[1]
normal activity of
ADAM17
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in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
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ADAM-17 regulates angiogenesis via its effects on the proliferation of endothelial cells, network formation, invasion and activation of MMP-2.
[2]
normal activity of
basigin
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in
blood_vessel
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Basigning regulates angiogenesis by increasing protease production ass well as by upregulation of hypoxia-inducible factor-2alpha, VEGFR2, and the soluble forms of VEGF.
[3]
more activity (high ligand concentration, overexpression) of
angiotensin II type 1 receptor
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in
granulosa_cell
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In conjunction with the angiotensin II type 1 receptor, angiotensin II mediates angiogenesis in the ovary via secretion of vascular endothelial growth factor.
[4]
Reference