Status
Please wait ...
EndoNet
The information resource about the endocrine network in human.
Search
Search a component
Browse
Browse pathways
Browse hormones
Browse hormones functions
Browse hormone classification
Browse receptors
Network
Load network
Path analysis
Process network
Help
Help
Statistic
About
Details for phenotype: regulation of angiogenesis
Top
General information
Triggers
Toolbox
Click to access the toolbox
Top
General information
Triggers
Toolbox
Click to access the toolbox
EndoNet ID: ENP00013
Add to network
Name
regulation of angiogenesis
General information
This phenotype is not pathologic
Links to other resources
GO
regulation of angiogenesis
Phenotype triggers
normal activity of
Vascular endothelial growth factor receptor 1
ui-button
in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
ui-button
VEGF is a crucial regulator of angiogenesis.
normal activity of
neuropilin-2
ui-button
in
vascularendothelial_cell
ui-button
neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis
[1]
normal activity of
ADAM17
ui-button
in
continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
ui-button
ADAM-17 regulates angiogenesis via its effects on the proliferation of endothelial cells, network formation, invasion and activation of MMP-2.
[2]
normal activity of
basigin
ui-button
in
blood_vessel
ui-button
Basigning regulates angiogenesis by increasing protease production ass well as by upregulation of hypoxia-inducible factor-2alpha, VEGFR2, and the soluble forms of VEGF.
[3]
more activity (high ligand concentration, overexpression) of
angiotensin II type 1 receptor
ui-button
in
granulosa_cell
ui-button
In conjunction with the angiotensin II type 1 receptor, angiotensin II mediates angiogenesis in the ovary via secretion of vascular endothelial growth factor.
[4]
Reference
