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Details for phenotype: ovarian follicle development

EndoNet ID: ENP00020

Name

ovarian follicle development

General information

This phenotype is not pathologic

Links to other resources

GO
MeSH term 68006080

Phenotype triggers

  • normal activity of angiotensin II type 1 receptor
    in ovary
    • Angiotensin II has many roles in the ovary, including folliculogenesis. [1]
  • normal activity of follitropin receptor
    in granulosa_cell
    • Follicle-stimuating hormone has a central role in ovarian folliculogenesis. [2]
  • normal activity of AR
    in theca_cell
    • Studies with AR knockout mice have revealed that AR function is essential for maintaining female fertility, notably through optimizing the conditions for follicular growth, final follicle development and ovulation. [3]
  • normal activity of AR
    in granulosa_cell
    • Studies with AR knockout mice have revealed that AR function is essential for maintaining female fertility, notably through optimizing the conditions for follicular growth, final follicle development and ovulation. [3]
  • normal activity of ER-alpha
    in granulosa_cell
    • Higher ER alpha gene expression in granulosa cells in patients with endometriosis, compared with patients with tubular infertility, implies that endometriosis may cause ovarian dysfunction. [4]
  • normal activity of ER-beta
    in granulosa_cell
    • ER beta is upregulated in patients with endometriosis. Elevated ER expression might be a leading cause of ovarian dysfunction. [4]
Reference